Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | MRE11 | P49959 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565664 | 0.71 | GAA (0.56) | TTRMAPTKDM4EALDH1A1POLB | |
| SCHEMBL6568655 | 0.69 | CNR2 (0.50) | TTRMAPTKDM4ELMNACNR2 | |
| SCHEMBL6568642 | 0.68 | CNR2 (0.43) | TTRMAPTKDM4ECNR2ABL1 | |
| SCHEMBL21011913 | 0.68 | SMN1; SMN2 (0.38) | MAPTALDH1A1POLBGAAESR2 | |
| SCHEMBL6567599 | 0.68 | CNR2 (0.43) | TTRMAPTKDM4ELMNACNR2 | |
| SCHEMBL23846748 | 0.66 | ALDH1A1 (0.33) | MAPTALDH1A1 | |
| SCHEMBL14383102 | 0.65 | ABL1 (0.52) | MAPTKDM4EABL1POLBGAA | |
| SCHEMBL23846745 | 0.65 | HPGD (0.30) | MAPTALDH1A1HPGD | |
| SCHEMBL3242326 | 0.65 | TTR (0.41) | TTRMAPTKDM4ELMNAABL1 | |
| SCHEMBL12921174 | 0.64 | ADRB2 (0.45) | MAPTKDM4ELMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |