Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18014778 | 0.83 | RAB9A (0.44) | CNR2RAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL6567599 | 0.83 | CNR2 (0.43) | CNR2RAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL6568642 | 0.78 | CNR2 (0.43) | CNR2RAB9ANPC1MAPTGAA | |
| SCHEMBL13021195 | 0.78 | RAB9A (0.59) | RAB9ANPC1L3MBTL1TDP1MAPT | |
| SCHEMBL6565664 | 0.76 | GAA (0.56) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL6565718 | 0.75 | ALDH1A1 (0.51) | RAB9ANPC1L3MBTL1MAPTGAA | |
| SCHEMBL6568589 | 0.75 | CNR2 (0.39) | CNR2RAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL6567198 | 0.74 | LOXL2 (0.48) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL6565582 | 0.73 | ALDH1A1 (0.43) | CNR2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL6567252 | 0.72 | MAPT (0.52) | RAB9ANPC1L3MBTL1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |