Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.79 |
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | HTT | P42858 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | STAT3 | P40763 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419546 | 0.78 | LMNA (0.72) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL298827 | 0.77 | KDM4E (1.00) | LMNAALDH1A1HTTSMN1; SMN2STAT3 | |
| SCHEMBL6566282 | 0.76 | ALDH1A1 (0.56) | LMNAALDH1A1HTTSMN1; SMN2STAT3 | |
| SCHEMBL6568083 | 0.73 | ALDH1A1 (0.54) | KMT2ALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5724121 | 0.73 | KDM4E (0.55) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL2401957 | 0.73 | KEAP1 (0.53) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL2398617 | 0.71 | LMNA (0.55) | LMNAALDH1A1HTTSMN1; SMN2STAT3 | |
| SCHEMBL1874186 | 0.70 | ALDH1A1 (0.68) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL1873887 | 0.70 | PRMT1 (0.77) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL1881276 | 0.70 | KEAP1 (0.53) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | disclosed |