4,4'-Methylenedianiline

4,4'-Methylenedianiline

SCHEMBL6567022

Cc1ccccc1.Nc1ccc(Cc2ccc(N)cc2)cc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.64
CYP3A4 P08684 3/20 0.64
TDP1 Q9NUW8 2/20 0.64
ALDH1A1 P00352 1/20 0.64
MAOB P27338 4/20 0.54
MAOA P21397 2/20 0.54
ACHE P22303 2/20 0.52
LMNA P02545 1/20 0.50
ALOX12 P18054 1/20 0.50
CALM1 P0DP23 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.46
CYP17A1 P05093 1/20 0.45
CYP19A1 P11511 1/20 0.45
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
GFER P55789 1/20 0.44
LTA4H P09960 1/20 0.43
TAAR1 Q96RJ0 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2A6 P11509 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2923178 0.88 CYP3A4 (0.74) TSHRCYP3A4TDP1ALDH1A1ACHE
SCHEMBL8771469 0.88 CYP3A4 (0.74) TSHRCYP3A4TDP1ALDH1A1ACHE
SCHEMBL8771463 0.85 CYP3A4 (0.78) TSHRCYP3A4TDP1ALDH1A1MAOB
4,4'-Methylenedianiline SCHEMBL28946261 0.85 CYP3A4 (0.78) TSHRCYP3A4TDP1ALDH1A1MAOB
SCHEMBL202238 0.85 CYP3A4 (0.78) TSHRCYP3A4TDP1ALDH1A1MAOB
Toluene SCHEMBL7717685 0.85 ACHE (0.71) TSHRCYP3A4TDP1ALDH1A1MAOB
4,4'-Methylenedianiline SCHEMBL16040933 0.84 ALDH1A1 (0.61) TSHRCYP3A4TDP1ALDH1A1ACHE
Hydrochloric Acid SCHEMBL8746107 0.83 CYP3A4 (0.74) TSHRCYP3A4TDP1ALDH1A1MAOB
Diphenylmethane SCHEMBL28427876 0.83 CALM1 (0.71) TSHRCYP3A4ALDH1A1ACHELMNA
Toluene SCHEMBL28825231 0.83 ACHE (0.67) TSHRCYP3A4TDP1ALDH1A1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401941-A1 STABILISED METALLOCENE POLYOLEFINS BASF AKTIENGESELLSCHAFT (DE) 2004-03-31 EP disclosed
WO-2002092684-A1 STABILISED METALLOCENE POLYOLEFINS BASF AKTIENGESELLSCHAFT (DE) 2002-11-21 WO disclosed