Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.35 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566791 | 0.79 | POLB (0.46) | NPC1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL6565612 | 0.79 | HPGD (0.53) | NPC1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL6567265 | 0.75 | CA1 (0.47) | KMT2AMEN1MAPK1POLBSMN1; SMN2 | |
| SCHEMBL4347164 | 0.72 | KMT2A (0.53) | NPC1KMT2AMEN1MAPK1POLB | |
| SCHEMBL6568667 | 0.71 | CA1 (0.56) | NPC1KMT2AMEN1MAPK1SMN1; SMN2 | |
| SCHEMBL6672080 | 0.68 | EPHX1 (0.48) | NPC1KMT2AMEN1MAPK1POLB | |
| SCHEMBL13216174 | 0.68 | HSD11B1 (0.57) | NPC1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL6567577 | 0.68 | KMT2A (0.58) | NPC1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL4349050 | 0.67 | RAB9A (0.54) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6526431 | 0.66 | HTT (0.47) | NPC1KMT2AMEN1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |