Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13216174 | 0.83 | HSD11B1 (0.57) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL6567577 | 0.83 | KMT2A (0.58) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL6568665 | 0.81 | KMT2A (0.60) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL6567257 | 0.79 | NPC1 (0.41) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL9528958 | 0.76 | HPGD (0.70) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL2236040 | 0.74 | SMN1; SMN2 (0.72) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL7430480 | 0.74 | HPGD (0.67) | HPGDNPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL10911138 | 0.72 | POLB (0.68) | SMN1; SMN2KMT2APOLBECE2MAPT | |
| SCHEMBL9707178 | 0.72 | RAB9A (0.63) | HPGDNPC1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL15985154 | 0.72 | SMN1; SMN2 (0.69) | HPGDNPC1SMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |