Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6357604 | 0.91 | LMNA (0.50) | LMNASMN1; SMN2POLBGRM4CA1 | |
| SCHEMBL6568216 | 0.91 | LMNA (0.50) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL6351493 | 0.90 | CA1 (0.50) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL6351497 | 0.90 | CA1 (0.50) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL6568866 | 0.88 | SLC16A1 (0.50) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL11646348 | 0.84 | NPC1 (0.59) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL6571101 | 0.81 | PDK1 (0.56) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL11644454 | 0.81 | LMNA (0.56) | LMNASMN1; SMN2POLBCA1CA2 | |
| SCHEMBL6351344 | 0.81 | POLB (0.42) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6351340 | 0.81 | POLB (0.42) | LMNAPOLBCA1CA2SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |