Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 6/20 | 0.48 |
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568147 | 0.91 | LMNA (0.56) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6357604 | 0.90 | LMNA (0.50) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6568866 | 0.89 | SLC16A1 (0.50) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6351493 | 0.88 | CA1 (0.50) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6351497 | 0.88 | CA1 (0.50) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6571101 | 0.80 | PDK1 (0.56) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6351340 | 0.80 | POLB (0.42) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6351344 | 0.80 | POLB (0.42) | LMNAPOLBCA1CA2SLC16A1 | |
| SCHEMBL6570069 | 0.79 | PDK1 (0.60) | LMNAPOLBSLC16A1PDK1PDK2 | |
| SCHEMBL4609323 | 0.77 | PDK1 (0.55) | LMNAPOLBPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |