Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359261 | 0.82 | KMT2A (0.54) | KMT2AMEN1MAPK1POLBHTT | |
| SCHEMBL6565420 | 0.80 | MEN1 (0.51) | KMT2AMEN1MAPK1POLBHTT | |
| SCHEMBL10767715 | 0.75 | TAS1R3 (0.46) | KMT2AMEN1POLBHTTMAPT | |
| SCHEMBL6568668 | 0.73 | GAA (0.61) | KMT2AMEN1MAPK1POLBHTT | |
| SCHEMBL7507310 | 0.71 | ALDH1A1 (0.68) | KMT2AMEN1MAPK1HTTMAPT | |
| SCHEMBL29649017 | 0.71 | ALDH1A1 (0.68) | KMT2AMEN1MAPK1HTTMAPT | |
| SCHEMBL4342367 | 0.71 | HTT (0.47) | KMT2AMEN1MAPK1POLBHTT | |
| SCHEMBL11791658 | 0.71 | GPR35 (0.59) | KMT2AMEN1CXCR1CXCR2SLC22A12 | |
| SCHEMBL28718277 | 0.70 | TAS1R3 (0.42) | KMT2AMEN1MAPTSMN1; SMN2CXCR1 | |
| SCHEMBL27371005 | 0.70 | MEN1 (0.50) | KMT2AMEN1POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |