Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567254 | 0.89 | — | — | |
| SCHEMBL6568663 | 0.78 | FAAH (0.39) | POLBMAPTGAANPSR1TDP1 | |
| SCHEMBL6568607 | 0.68 | POLB (0.35) | CA1CA2POLBCYP2C9HSD17B10 | |
| SCHEMBL4357522 | 0.67 | POLB (0.33) | CA1CA2POLBCYP2C9HIF1A | |
| SCHEMBL4344470 | 0.64 | KMT2A (0.54) | CA1CA2POLBAPEX1HSD17B10 | |
| SCHEMBL4345478 | 0.61 | TSHR (0.47) | APEX1HSD17B10TSHRMAPTGAA | |
| SCHEMBL4353170 | 0.59 | ALDH1A1 (0.36) | POLBAPEX1MAPTGAANPSR1 | |
| SCHEMBL4350112 | 0.58 | LMNA (0.33) | POLBCYP2C9HSD17B10TSHRHIF1A | |
| SCHEMBL4350106 | 0.58 | POLB (0.52) | POLBCYP2C9HIF1ACYP2D6KDM4E | |
| SCHEMBL157575 | 0.58 | CYP3A4 (0.44) | CA1CA2CYP2C9HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |