Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11315722 | 0.82 | LMNA (0.43) | LMNAMEN1KMT2AKDM4E | |
| Tromethamine SCHEMBL7037162 | 0.82 | MEN1 (0.43) | LMNAMEN1KMT2AKDM4E | |
| Tromethamine SCHEMBL466446 | 0.82 | LMNA (0.62) | LMNAMEN1KMT2AALDH1A1THRB | |
| SCHEMBL1638881 | 0.82 | LMNA (0.53) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL30754 | 0.82 | LMNA (0.53) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL27783488 | 0.80 | USP2 (0.43) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL25238278 | 0.79 | LMNA (0.50) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL821029 | 0.79 | LMNA (0.50) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL22279336 | 0.79 | LMNA (0.50) | LMNAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL15894238 | 0.79 | LMNA (0.50) | LMNAMEN1KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406885-A1 | PROCESS FOR MANUFACTURING AN A-DIHYDROXY DERIVATIVE AND EPOXY RESINS PREPARED THEREFROM | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004481-A1 | PROCESS FOR MANUFACTURING AN A-DIHYDROXY DERIVATIVE AND EPOXY RESINS PREPARED THEREFROM | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-01-16 | — | — | WO | disclosed |