Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7164425 | 0.86 | LMNA (0.53) | LMNAMEN1KMT2AALDH1A1THRB | |
| Tromethamine SCHEMBL6569887 | 0.82 | LMNA (0.48) | LMNAMEN1KMT2AALDH1A1THRB | |
| Tromethamine SCHEMBL975 | 0.79 | — | — | |
| Tromethamine SCHEMBL17484 | 0.79 | MEN1 (1.00) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL3696191 | 0.79 | — | — | |
| Deanol SCHEMBL16685577 | 0.79 | LMNA (0.53) | LMNAMEN1KMT2AALDH1A1THRB | |
| Tromethamine SCHEMBL8334055 | 0.79 | LMNA (0.59) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| Tromethamine SCHEMBL7567125 | 0.78 | LMNA (0.67) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| Tromethamine SCHEMBL2035496 | 0.75 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113710243-A | Transient ischemic attack of Triglyceroltris (beta-hydroxybutyrate) and neurons | 神经活力投资公司 | 2021-11-26 | — | — | CN | claimed |
| EP-3802867-A1 | PRODUCTS AND PROCESSES FOR NUCLEIC ACID DETECTION AND QUANTIFICATION | Agena Bioscience, Inc. (US) | 2021-04-14 | — | — | EP | claimed |
| CN-112292459-A | Products and methods for nucleic acid detection and quantification | 基纳生物技术有限公司 | 2021-01-29 | — | — | CN | claimed |
| CN-107329368-B | Alkali-soluble photosensitive composition, and preparation method and application thereof | 江苏广信感光新材料股份有限公司 | 2020-08-14 | — | — | CN | claimed |
| WO-2010053549-A1 | ETHANOL STABLE POLYETHER IMIDE MEMBRANE FOR AROMATICS SEPARATION | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2010-05-14 | — | — | WO | claimed |
| WO-2004062641-A1 | NON-LETHAL TEMPORARY INCAPACITATION FORMULATION AND NOVEL SOLVENT SYSTEM | ZARC INTERNATIONAL, INC. (US) | 2004-07-29 | — | — | WO | claimed |
| US-20030129138-A1 | Non-lethal temporary incapacitation formulation and novel solvent system | ZARC INTERNATIONAL, INC. | 2003-07-10 | — | — | US | claimed |
| US-20240237634-A1 | PROTEIN-FREE SEMEN CRYOPRESERVATION | UNIVERSITY OF SASKATCHEWAN (CA) | 2024-07-18 | — | — | US | disclosed |
| CN-114007660-B | Refreshing composition and method for atomizing refreshing composition by using heat-activated microfluidic cartridge | 宝洁公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113543652-B | Taste masking formulations for ketone body compounds | 神经活力投资公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118265517-A | Oil-in-water type emulsified cosmetic | 株式会社资生堂 | 2024-06-28 | — | — | CN | disclosed |
| US-12012442-B2 | Activatable fusion protein and use thereof | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2024-06-18 | — | — | US | disclosed |
| CN-115243892-B | Biaxially stretched polyamide film | 东洋纺株式会社 | 2024-05-24 | — | — | CN | disclosed |
| US-5783413-A | PURIFICATION OF FUSION PROTEINS, ENZYMATIC REMOVAL OF THE N-TERMINAL AMINO ACID SEQUENCE, STOP POINT IS IN THE EXTENSION RATHER THAN IN THE DESIRED PROTEIN PRODUCT | UNIZYME LABORATORIES A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| US-5051460-A | Chlorotrifluoroethylene-ethylene copolymer with heat resistant stabilizers, epoxy resins, phosphites and esters | AUSIMONT, U.S.A., INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0069195-B1 | STABILIZED ETHYLENE/CHLOROTRIFLUOROETHYLENE COPOLYMER COMPOSITION | Ausimont, U.S.A., Inc. (US) | 1988-08-24 | — | — | EP | disclosed |
| EP-0154518-A2 | Phenolic compound, resin stabilizer containing it, and synthetic resins stabilized thereby | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-09-11 | — | — | EP | disclosed |
| US-4539354-A | PHOSPHITE DERIVATIVE OF A PHENOL, A GROUP II METAL CARBOXYLATE ANDAN ESTER OF A POLYOL | ALLIED CORPORATION (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0069195-A2 | Stabilized ethylene/chlorotrifluoroethylene copolymer composition | Ausimont, U.S.A., Inc. (US) | 1983-01-12 | — | — | EP | disclosed |
| US-3975414-A | N,N-bis(4-anilinophenyl)-4,7-dithia-5-methyldecanediamide and related compounds useful as polymer stabilizers | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240237634-A1 | PROTEIN-FREE SEMEN CRYOPRESERVATION | CETP, NASP, CHLSN | LMNA 470/4885MEN1 2754/4885KMT2A 4087/4885 |
| US-12012442-B2 | Activatable fusion protein and use thereof | CD2BP2, CD2, CD4 | LMNA 4442/4885MEN1 3413/4885KMT2A 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.