Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491722 | 0.93 | ALDH1A1 (0.80) | ALDH1A1SIGMAR1HRH3MEN1KMT2A | |
| SCHEMBL14004380 | 0.81 | ALDH1A1 (0.62) | ALDH1A1SIGMAR1HRH3RAD52MAPT | |
| SCHEMBL10724053 | 0.81 | ALDH1A1 (0.69) | ALDH1A1SIGMAR1HRH3RAD52TP53 | |
| SCHEMBL14004378 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SIGMAR1HRH3MEN1KMT2A | |
| SCHEMBL7522076 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SIGMAR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL20016275 | 0.74 | ALDH1A1 (0.58) | ALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL11027232 | 0.73 | SMN1; SMN2 (0.54) | ALDH1A1HRH3CYP3A4TP53CYP1A2 | |
| SCHEMBL279341 | 0.72 | HPGD (0.50) | ALDH1A1MEN1KMT2ATP53TDP1 | |
| SCHEMBL16353594 | 0.72 | SMN1; SMN2 (0.59) | ALDH1A1HRH3MEN1KMT2ACYP3A4 | |
| SCHEMBL5612839 | 0.72 | ALDH1A1 (0.57) | ALDH1A1SIGMAR1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428820-A1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2004-06-16 | — | — | EP | disclosed |
| EP-1100503-A2 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | SOCIETE CIVILE BIOPROJET (FR) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006254-A2 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | SOCIETE CIVILE BIOPROJET (FR) | 2000-02-10 | — | — | WO | disclosed |