Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916195 | 0.98 | HPGD (0.37) | HPGDALDH1A1SMN1; SMN2RAB9ADEPTOR | |
| SCHEMBL6570232 | 0.86 | HPGD (0.35) | HPGDALDH1A1SMN1; SMN2RAB9ADEPTOR | |
| SCHEMBL2913811 | 0.73 | TRPM8 (0.50) | ALDH1A1SMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL150887 | 0.73 | TSHR (0.39) | HPGDALDH1A1SMN1; SMN2RAB9ADEPTOR | |
| SCHEMBL3973751 | 0.71 | NPSR1 (0.36) | ALDH1A1SMN1; SMN2RAB9ATDP1MEN1 | |
| SCHEMBL23199903 | 0.69 | NPC1 (0.42) | ALDH1A1SMN1; SMN2RAB9ATDP1CES1 | |
| SCHEMBL2226134 | 0.69 | HPGD (0.55) | HPGDALDH1A1SMN1; SMN2NR4A2MAPT | |
| SCHEMBL9491251 | 0.69 | ALDH1A1 (0.46) | HPGDALDH1A1SMN1; SMN2RAB9ANR4A2 | |
| SCHEMBL9123260 | 0.67 | ALDH1A1 (0.44) | HPGDALDH1A1SMN1; SMN2RAB9ANR4A2 | |
| SCHEMBL22245104 | 0.67 | NPC1 (0.40) | ALDH1A1SMN1; SMN2RAB9ATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1407264-A1 | CAGED COMPOUND CLEAVING PROCESS | Cardiogenics Inc. (CA) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008969-A1 | CAGED COMPOUND CLEAVING PROCESS | CARDIOGENICS INC. (CA) | 2003-01-30 | — | — | WO | disclosed |