Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421147 | 0.84 | ALDH1A1 (0.54) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| SCHEMBL20521930 | 0.81 | CYP1A2 (0.47) | GAACYP1A2CYP2A6TACR1ALDH1A1 | |
| SCHEMBL7639432 | 0.80 | MMP8 (0.56) | GAAADRB2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL12802204 | 0.80 | CYP1A2 (0.46) | GAAADRB2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL16595186 | 0.79 | CYP1A2 (0.45) | GAACYP1A2CYP2A6TACR1ALDH1A1 | |
| SCHEMBL1221957 | 0.77 | MMP8 (0.44) | GAAADRB2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL3800271 | 0.76 | GAA (0.56) | GAACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL2385413 | 0.74 | CYP4F2 (0.59) | GAAADRB2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL30513307 | 0.73 | ALDH1A1 (0.60) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| Triethyl Citrate SCHEMBL6125602 | 0.72 | HSD11B1 (0.47) | ALDH1A1RECQLMMP8POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089963-B1 | HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE | SMITHKLINE BEECHAM PLC (GB) | 2004-06-16 | — | — | EP | disclosed |
| US-6458779-B1 | TREATMENT OF CONDITIONS ASSOCIATED WITH EXCESS PRODUCTION OF SOLUBLE CD23 (S-CD23) SUCH AS AUTOIMMUNE DISEASE AND ALLERGY. THE COMPOUNDS OF THE INVENTION ARE ALSO INHIBITORS OF THE RELEASE OF TUMOUR NECROSIS FACTOR (TNF). | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-01 | — | — | US | disclosed |
| EP-1089963-A1 | HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067201-A1 | HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE | SMITHKLINE BEECHAM PLC (GB) | 1999-12-29 | — | — | WO | disclosed |