SCHEMBL6571158

SCHEMBL6571158

COCCN(CCOC)c1ccc(N)c(-c2ccc(OC)cc2C=O)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ERN1 O75460 3/20 0.39
TRIM24 O15164 1/20 0.36
TYR P14679 1/20 0.36
TRIM33 Q9UPN9 1/20 0.36
CRHR1 P34998 3/20 0.34
RELA Q04206 2/20 0.34
MAPT P10636 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
KDM4E B2RXH2 1/20 0.33
NCF1 P14598 1/20 0.33
CYP3A4 P08684 1/20 0.33
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
KMT2A Q03164 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574544 0.91 ALDH1A1 (0.43) ALDH1A1L3MBTL1ERN1TRIM24TYR
SCHEMBL6574718 0.88 ERN1 (0.42) ALDH1A1L3MBTL1ERN1TRIM24TYR
SCHEMBL6571019 0.87 ALDH1A1 (0.36) ALDH1A1L3MBTL1KDM4ELMNA
SCHEMBL6571801 0.84 ALDH1A1 (0.37) ALDH1A1L3MBTL1ERN1CRHR1MEN1
SCHEMBL6570806 0.81 ALDH1A1 (0.42) ALDH1A1CRHR1MAPTCYP3A4MEN1
SCHEMBL6570789 0.79 ALDH1A1 (0.43) ALDH1A1L3MBTL1ERN1TRIM24TYR
SCHEMBL6572193 0.79 ERN1 (0.39) ALDH1A1L3MBTL1ERN1TRIM24TYR
SCHEMBL6572323 0.79 ALOX15 (0.40) ALDH1A1CRHR1RELAMAPTCYP1A2
SCHEMBL6571343 0.77 FDPS (0.43) ALDH1A1L3MBTL1TRIM24TRIM33MAPT
SCHEMBL6571146 0.76 ALDH1A1 (0.40) ALDH1A1L3MBTL1RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed