SCHEMBL6571801

SCHEMBL6571801

COCCN(CCOC)c1ccc(N)c(-c2ccccc2C=O)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
HPGD P15428 2/20 0.33
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
F2 P00734 1/20 0.33
PRSS1 P07477 1/20 0.33
PRSS2 P07478 1/20 0.33
PRSS3 P35030 1/20 0.33
ERN1 O75460 2/20 0.31
GAA P10253 1/20 0.31
S100B P04271 1/20 0.31
KCNA5 P22460 1/20 0.30
BTK Q06187 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
RORC P51449 1/20 0.30
CRHR1 P34998 1/20 0.30
CA2 P00918 2/20 0.30
OXTR P30559 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6571019 0.85 ALDH1A1 (0.36) ALDH1A1L3MBTL1SMN1; SMN2GAAS100B
SCHEMBL6574544 0.84 ALDH1A1 (0.43) ALDH1A1L3MBTL1ERN1
SCHEMBL6571158 0.84 ALDH1A1 (0.40) ALDH1A1L3MBTL1HPGDERN1MEN1
SCHEMBL6572933 0.83 KMT2A (0.37) ALDH1A1L3MBTL1HTTSMN1; SMN2F2
SCHEMBL6572502 0.82 S100B (0.40) ALDH1A1HPGDHTTF2PRSS1
SCHEMBL6573203 0.82 ALDH1A1 (0.34) ALDH1A1HTTF2PRSS1PRSS2
SCHEMBL6571532 0.81 HTR7 (0.44) ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL6570863 0.81 CRHR1 (0.39) ALDH1A1HTTF2PRSS1PRSS2
SCHEMBL6571124 0.81 F2 (0.36) ALDH1A1HPGDHTTSMN1; SMN2F2
SCHEMBL6573765 0.79 MAPK1 (0.49) ALDH1A1L3MBTL1HTTSMN1; SMN2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed