SCHEMBL6571789

SCHEMBL6571789

Cc1c([Si](c2ccccc2)(c2ccccc2)c2ccc3c(c2C)Cc2ccccc2-3)ccc2c1Cc1ccccc1-2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 1/20 0.39
PNMT P11086 1/20 0.38
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
KDR P35968 2/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 2/20 0.34
MAPT P10636 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
SRD5A2 P31213 1/20 0.34
ACHE P22303 2/20 0.34
BCHE P06276 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
DRD3 P35462 1/20 0.34
PDGFRB P09619 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9418164 0.82 PGR (0.41) PGRPNMTNPC1RAB9AKDR
SCHEMBL5980985 0.80 PNMT (0.46) PGRPNMTNPC1RAB9AKDR
SCHEMBL7580881 0.78 PNMT (0.41) PGRPNMTNPC1RAB9AKDR
SCHEMBL28783149 0.77 KDR (0.40) PGRPNMTNPC1RAB9AKDR
SCHEMBL28970858 0.77 PNMT (0.46) PGRPNMTNPC1RAB9AKDR
SCHEMBL358531 0.76 PNMT (0.47) PGRPNMTNPC1RAB9AKDM4E
SCHEMBL29413832 0.76 PNMT (0.47) PGRPNMTNPC1RAB9AKDM4E
Fluorene SCHEMBL28414270 0.74 PNMT (0.46) PGRPNMTNPC1RAB9AKDM4E
Methyl Alcohol SCHEMBL14815698 0.73 NPC1 (0.46) PGRPNMTNPC1RAB9AKDM4E
Tannin Pyrogallol SCHEMBL29187610 0.72 PGR (0.41) PGRPNMTNPC1RAB9AKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637744-A Bis fluorenyl metallocenes and use thereof PHILLIPS PETROLEUM COMPANY (US) 1997-06-10 US claimed
EP-0628565-A1 Bis fluorenyl metallocenes and use thereof PHILLIPS PETROLEUM COMPANY (US) 1994-12-14 EP claimed
JP-7070161-A None JP disclosed
EP-1263764-B1 METHOD OF PREPARING GROUP 14 BRIDGED BISCYCLOPENTADIENYL LIGANDS EXXONMOBIL CHEM PATENTS INC (US) 2004-04-14 EP disclosed
US-5637744-A Bis fluorenyl metallocenes and use thereof PHILLIPS PETROLEUM COMPANY (US) 1997-06-10 US disclosed
US-5631335-A Process of polymerizing olefins using diphenylsilyl or dimethyl tin bridged 1-methyl fluorenyl metallocenes PHILLIPS PETROLEUM COMPANY (US) 1997-05-20 US disclosed
JP-H0770161-A BRIDGED SANDWICH LINKAGE METALLOCENE AND PROCESS FOR POLYMERIZING OLEFIN USING SAME AS CATALYST PHILLIPS PETROLEUM CO 1995-03-14 JP disclosed
EP-0628565-A1 Bis fluorenyl metallocenes and use thereof PHILLIPS PETROLEUM COMPANY (US) 1994-12-14 EP disclosed