SCHEMBL6571944

SCHEMBL6571944

CS(=O)(=O)Nc1ccc(NC(=O)CCl)cc1O

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GSTO1 P78417 10/20 0.50
PRMT1 Q99873 1/20 0.50
ALDH1A1 P00352 6/20 0.46
HTT P42858 5/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
EP300 Q09472 1/20 0.45
KAT2B Q92831 1/20 0.45
KAT8 Q9H7Z6 1/20 0.45
CASP3 P42574 1/20 0.45
MITF O75030 3/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
XBP1 P17861 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
NOD2 Q9HC29 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6807072 0.83 PKM (0.51) ALDH1A1SMN1; SMN2MAPTEP300KAT2B
SCHEMBL4577565 0.81 PRMT1 (0.64) GSTO1PRMT1ALDH1A1HTTSMN1; SMN2
SCHEMBL6806587 0.81 SMN1; SMN2 (0.48) ALDH1A1HTTSMN1; SMN2LMNAEP300
SCHEMBL6574945 0.80 HSP90AA1 (0.51) ALDH1A1EP300KAT2BKAT8
SCHEMBL3238696 0.79 NPC1 (0.54) ALDH1A1HTTSMN1; SMN2LMNAMAPT
Hydrochloric Acid SCHEMBL6573566 0.79 HSP90AA1 (0.53) ALDH1A1LMNA
SCHEMBL6941725 0.79 RAB9A (0.51) GSTO1ALDH1A1HTTSMN1; SMN2LMNA
SCHEMBL9095123 0.78 TDP1 (0.47) ALDH1A1SMN1; SMN2MAPTEP300KAT2B
SCHEMBL14706934 0.77 ERCC1 (0.58) GSTO1PRMT1ALDH1A1HTTSMN1; SMN2
SCHEMBL28893860 0.77 PDE4B (0.63) GSTO1ALDH1A1HTTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066264-B1 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS OREAL (FR) 2004-11-17 EP disclosed
US-6537329-B1 Intense colorations with a wide range of colours, excellent colorfastness L'OREAL S.A. (FR) 2003-03-25 US disclosed
EP-1066264-A2 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS L'OREAL (FR) 2001-01-10 EP disclosed
WO-2000042971-A2 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS L'OREAL (FR) 2000-07-27 WO disclosed