SCHEMBL6806587

SCHEMBL6806587

COC(=O)Nc1ccc(NS(C)(=O)=O)c(O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.48
LMNA P02545 2/20 0.48
POLB P06746 1/20 0.48
GAA P10253 1/20 0.48
GFER P55789 1/20 0.48
TUBB4A P04350 1/20 0.47
TUBB P07437 1/20 0.47
TUBA3C P0DPH7 1/20 0.47
TUBA1B P68363 1/20 0.47
TUBA4A P68366 1/20 0.47
TUBB4B P68371 1/20 0.47
TUBB3 Q13509 1/20 0.47
TUBB2A Q13885 1/20 0.47
TUBB8 Q3ZCM7 1/20 0.47
TUBA3E Q6PEY2 1/20 0.47
TUBA1A Q71U36 1/20 0.47
TUBA1C Q9BQE3 1/20 0.47
TUBB6 Q9BUF5 1/20 0.47
TUBB2B Q9BVA1 1/20 0.47
TUBB1 Q9H4B7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6807072 0.84 PKM (0.51) SMN1; SMN2POLBGAAEP300KAT2B
SCHEMBL6806562 0.82 KMT2A (0.57) SMN1; SMN2LMNAPOLBGAAGFER
SCHEMBL3238696 0.81 NPC1 (0.54) SMN1; SMN2LMNAEP300KAT2BKAT8
SCHEMBL6571944 0.81 GSTO1 (0.50) SMN1; SMN2LMNAEP300KAT2BKAT8
SCHEMBL9095123 0.79 TDP1 (0.47) SMN1; SMN2POLBEP300KAT2BKAT8
SCHEMBL3237191 0.77 TOP1 (0.60) SMN1; SMN2LMNAEP300KAT2BKAT8
SCHEMBL3247691 0.77 TOP1 (0.60) SMN1; SMN2LMNAEP300KAT2BKAT8
SCHEMBL3236934 0.77 NPC1 (0.51) SMN1; SMN2LMNAEP300KAT2BKAT8
SCHEMBL6807571 0.75 ALDH1A1 (0.56) SMN1; SMN2LMNAGAATUBB4ATUBB
SCHEMBL6802561 0.75 SMN1; SMN2 (0.38) SMN1; SMN2EP300KAT2BKAT8KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US claimed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US claimed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP claimed
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US disclosed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US disclosed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP disclosed