SCHEMBL6572015

SCHEMBL6572015

COCCN(CCOC)c1ccc(N)cc1-c1ccc(OC)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.41
MAPK1 P28482 1/20 0.41
GAA P10253 1/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP3A4 P08684 1/20 0.40
CRHR1 P34998 1/20 0.39
APP P05067 2/20 0.39
KDM4E B2RXH2 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
GABRA1 P14867 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38
GABRA2 P47869 1/20 0.38
ALOX15 P16050 1/20 0.37
MAPT P10636 2/20 0.37
RPS6KA2 Q15349 1/20 0.37
TP53 P04637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572090 0.91 CRHR1 (0.34) TDP1MAPK1GAAALDH1A1CYP3A4
SCHEMBL6572427 0.88 TDP1 (0.45) TDP1GAAALDH1A1CYP3A4KDM4E
SCHEMBL6571974 0.87 ALDH1A1 (0.42) TDP1MAPK1GAAALDH1A1CYP3A4
SCHEMBL6571013 0.87 CRHR1 (0.38) TDP1ALDH1A1CRHR1KDM4ENPC1
SCHEMBL6572104 0.86 CRHR1 (0.32) CRHR1APP
SCHEMBL6571975 0.86 GRM2 (0.38) ALDH1A1CRHR1APPRAB9ASMN1; SMN2
SCHEMBL6572455 0.86 USP7 (0.35) GAAALDH1A1CYP3A4CRHR1APP
SCHEMBL6571986 0.86 MEN1 (0.41) CYP3A4CRHR1NPC1RAB9ASMN1; SMN2
SCHEMBL6574108 0.86 CRHR1 (0.33) MAPK1ALDH1A1CRHR1KDM4EALOX15
SCHEMBL6571312 0.85 ALDH1A1 (0.44) GAAALDH1A1CYP3A4KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed