SCHEMBL6571312

SCHEMBL6571312

COCCN(CCOC)c1ccc(N)cc1-c1cccc(OC)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
CYP3A4 P08684 1/20 0.44
TDO2 P48775 1/20 0.42
MAOB P27338 2/20 0.41
SRC P12931 3/20 0.40
CYP19A1 P11511 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
KIT P10721 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
ABL1 P00519 1/20 0.38
EGFR P00533 1/20 0.38
ABL2 P42684 1/20 0.38
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
HSD17B10 Q99714 1/20 0.38
KDM4E B2RXH2 2/20 0.37
KMT2A Q03164 2/20 0.37
FYN P06241 1/20 0.37
MGAT2 Q10469 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572255 0.89 CRHR1 (0.38) ALDH1A1CYP3A4FYN
SCHEMBL6572448 0.87 ALDH1A1 (0.44) ALDH1A1CYP3A4TDO2MAOBSRC
SCHEMBL6573087 0.86 CRHR1 (0.40) ALDH1A1SMN1; SMN2ADORA1ABL1MAPT
SCHEMBL6572015 0.85 TDP1 (0.41) ALDH1A1CYP3A4MAOBSMN1; SMN2ABL1
SCHEMBL6571031 0.85 PIK3CG (0.38) ALDH1A1CYP3A4SRCADORA1FYN
SCHEMBL6571546 0.85 CRHR1 (0.42) ALDH1A1TDO2MAOBKMT2AFYN
SCHEMBL6572721 0.85 KDM4E (0.35) ALDH1A1SMN1; SMN2ADORA2AADORA1LMNA
SCHEMBL6572624 0.85 MAP4K4 (0.44) MAOBKMT2AFYN
SCHEMBL6572090 0.82 CRHR1 (0.34) ALDH1A1CYP3A4MAPTKMT2AMEN1
SCHEMBL6571473 0.81 RORB (0.42) MAOBADORA2AADORA1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed