Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573581 | 0.86 | MAPT (0.50) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL6573530 | 0.78 | CYP2C19 (0.74) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15574219 | 0.77 | LMNA (0.39) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15573363 | 0.77 | KMT2A (0.39) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15574248 | 0.77 | THRB (0.40) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL6570770 | 0.76 | LMNA (0.76) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL6571185 | 0.75 | LMNA (0.71) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15573622 | 0.72 | THRB (0.38) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15574457 | 0.72 | SMN1; SMN2 (0.41) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15573884 | 0.72 | SMN1; SMN2 (0.41) | CYP2C19LMNAKDM4ESMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |
| EP-1109550-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013683-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |