Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563319 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6575649 | 0.84 | ADRA2A (0.46) | SMN1; SMN2KDM4EALDH1A1ADRB2ADRB1 | |
| SCHEMBL6575368 | 0.82 | PTGS2 (0.61) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6565154 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6572128 | 0.80 | GRIA4 (0.54) | SMN1; SMN2KDM4EHSD17B10TSHRADRB2 | |
| SCHEMBL6574100 | 0.77 | HSD17B10 (0.44) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL2046459 | 0.76 | CNR1 (0.53) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6763747 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6563391 | 0.75 | MEN1 (0.54) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6572002 | 0.75 | GRIA4 (0.51) | KDM4EHSD17B10TSHRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | DAVISON JOSHUA ZWICK (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1409452-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002098846-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | GRIN1, GRIN2A, GRIA1 | SMN1; SMN2 386/4885KDM4E 3086/4885HSD17B10 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.