Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761730 | 0.84 | NQO2 (0.54) | SMN1; SMN2POLBNQO2SIGMAR1CA12 | |
| SCHEMBL6572131 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2HCAR2ALDH1A1PTGS2KDM4E | |
| SCHEMBL6572128 | 0.84 | GRIA4 (0.54) | ADRA2AADRA2BADRA2CADRA1ASMN1; SMN2 | |
| SCHEMBL12720945 | 0.81 | SPR (0.52) | ADRA2AADRA2BADRA2CADRA1APOLB | |
| SCHEMBL6571852 | 0.80 | PTGS2 (0.66) | SMN1; SMN2ALDH1A1POLBPTGS2SLC2A1 | |
| SCHEMBL6763704 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1PTGS2SLC2A1CA12 | |
| Bromide SCHEMBL11276785 | 0.77 | TMEM97 (0.63) | ADRA2AADRA2BADRA2CADRA1ASMN1; SMN2 | |
| SCHEMBL3720173 | 0.76 | KDM4E (0.70) | SMN1; SMN2HCAR2ALDH1A1PTGS2KDM4E | |
| SCHEMBL6572264 | 0.75 | PTGS2 (0.45) | SMN1; SMN2ALDH1A1POLBNQO2PTGS2 | |
| SCHEMBL6571967 | 0.75 | PTGS2 (0.45) | SMN1; SMN2ALDH1A1PTGS2SLC2A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | DAVISON JOSHUA ZWICK (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1409452-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002098846-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | GRIN1, GRIN2A, GRIA1 | ADRA2A 1177/4885ADRA2B 1406/4885ADRA2C 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.