SCHEMBL6572194

SCHEMBL6572194

O=C(Nc1nc(Cl)cc(Cl)n1)NS(=O)(=O)Nc1ccccc1C(=O)C1CC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACVRL1 P37023 1/20 0.36
ALOX15 P16050 1/20 0.36
ADORA3 P0DMS8 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
KMT2A Q03164 4/20 0.35
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 3/20 0.35
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
MRGPRX1 Q96LB2 1/20 0.33
PCTP Q9UKL6 1/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 2/20 0.33
MAPK1 P28482 1/20 0.33
MAPT P10636 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6573963 0.87 NPC1 (0.36) ALOX15KMT2AMRGPRX1NPC1
SCHEMBL53468 0.84 GAA (0.47) ALOX15KMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL29510603 0.84 GAA (0.47) ALOX15KMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL6575065 0.83 HSD17B10 (0.37) ALOX15KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL6812884 0.83 GAA (0.47) ALOX15KMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL8539307 0.77 GAA (0.44) ALOX15ALDH1A1SMN1; SMN2HPGDHTT
SCHEMBL8166988 0.74 ALDH1A1 (0.37) KMT2AKDM4EMEN1ALDH1A1SMN1; SMN2
SCHEMBL2373409 0.74 GAA (0.37) ALOX15KMT2AMEN1ALDH1A1MAPT
Dichlormid SCHEMBL2373811 0.73 GAA (0.36) KMT2AALDH1A1MAPT
Ethoxysulfuron SCHEMBL6447158 0.73 MRGPRX1 (0.41) KMT2AMEN1MRGPRX1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0747365-B1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds BASF AG (DE) 2004-08-11 EP claimed
US-5847140-A Intermediates for the manufacture of herbicidal 1-{ 2-(cyclopropylcarbonyl) Phenyl! Sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl) urea compounds AMERICAN CYANAMID COMPANY (US) 1998-12-08 US claimed
EP-0747365-A1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds American Cyanamid Company (US) 1996-12-11 EP claimed
EP-0747365-B1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds BASF AG (DE) 2004-08-11 EP disclosed
US-5847140-A Intermediates for the manufacture of herbicidal 1-{ 2-(cyclopropylcarbonyl) Phenyl! Sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl) urea compounds AMERICAN CYANAMID COMPANY (US) 1998-12-08 US disclosed
EP-0747365-A1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds American Cyanamid Company (US) 1996-12-11 EP disclosed
US-5559234-A Process for the manufacture of herbicidal 1-{[2-(cyclopropylcarbonyl)phyenyl]sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds AMERICAN CYANAMID COMPANY (US) 1996-09-24 US disclosed
US-5540992-A Polyethylene bicomponent fibers DANAKLON A/S (DK) 1996-07-30 US disclosed
WO-1993001334-A1 POLYETHYLENE BICOMPONENT FIBRES DANAKLON A/S (DK) 1993-01-21 WO disclosed
EP-0522995-A2 Polyethylene bicomponent fibres DANAKLON A/S (DK) 1993-01-13 EP disclosed