SCHEMBL6575065

SCHEMBL6575065

O=C(Nc1nc(Cl)cc(Cl)n1)NS(=O)(=O)Nc1ccccc1C1CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.37
ALOX15 P16050 1/20 0.36
STAT3 P40763 1/20 0.35
STAT1 P42224 1/20 0.35
KMT2A Q03164 1/20 0.35
RIPK1 Q13546 1/20 0.34
TAS1R3 Q7RTX0 1/20 0.34
TAS1R1 Q7RTX1 1/20 0.34
TACR1 P25103 1/20 0.33
S1PR2 O95136 1/20 0.32
ALDH1A1 P00352 3/20 0.31
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
HPGD P15428 1/20 0.31
CASP3 P42574 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SENP8 Q96LD8 1/20 0.31
SENP7 Q9BQF6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9316954 0.84 GAA (0.48) ALOX15KMT2AALDH1A1SMN1; SMN2TSHR
SCHEMBL6572194 0.83 ACVRL1 (0.36) ALOX15KMT2ATAS1R3TAS1R1ALDH1A1
SCHEMBL6573963 0.73 NPC1 (0.36) ALOX15KMT2ANPC1RAB9AGAA
SCHEMBL10945128 0.71 ALOX15 (0.55) ALOX15KMT2AALDH1A1KDM4ERAB9A
SCHEMBL10949384 0.69 GAA (0.52) ALOX15KMT2ANPC1CASP3SENP8
SCHEMBL53468 0.68 GAA (0.47) ALOX15KMT2AALDH1A1SMN1; SMN2TSHR
SCHEMBL6812884 0.67 GAA (0.47) ALOX15KMT2AALDH1A1SMN1; SMN2TSHR
SCHEMBL8633328 0.67 GAA (0.47) ALOX15KMT2AALDH1A1SMN1; SMN2TSHR
SCHEMBL8780754 0.65 GAA (0.45) ALOX15KMT2AALDH1A1SMN1; SMN2TSHR
SCHEMBL7801293 0.65 PTK2 (0.48) KMT2AALDH1A1RAB9ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0747365-B1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds BASF AG (DE) 2004-08-11 EP disclosed
US-5847140-A Intermediates for the manufacture of herbicidal 1-{ 2-(cyclopropylcarbonyl) Phenyl! Sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl) urea compounds AMERICAN CYANAMID COMPANY (US) 1998-12-08 US disclosed
US-5559234-A Process for the manufacture of herbicidal 1-{[2-(cyclopropylcarbonyl)phyenyl]sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds AMERICAN CYANAMID COMPANY (US) 1996-09-24 US disclosed