SCHEMBL6572463

SCHEMBL6572463

Nc1ccc(NCCO)c(-c2cccc(N(CCO)CCO)c2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
TSHR P16473 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
FYN P06241 2/20 0.34
ADORA1 P30542 1/20 0.33
AKT1 P31749 5/20 0.32
FCGR3B O75015 1/20 0.32
FCGR1A P12314 1/20 0.32
FCGR2A P12318 1/20 0.32
STK4 Q13043 1/20 0.31
STK3 Q13188 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31
MAPT P10636 3/20 0.31
MAP4K4 O95819 1/20 0.31
KDM4E B2RXH2 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
PIM1 P11309 1/20 0.31
PIM3 Q86V86 1/20 0.31
PIM2 Q9P1W9 1/20 0.31
CHRM3 P20309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570903 0.87 TSHR (0.50) ALDH1A1TSHRTDP1AKT1MAPT
SCHEMBL6571191 0.86 FYN (0.46) ALDH1A1TSHRFYNADORA1MAPT
SCHEMBL6574148 0.85 KDM4E (0.41) ALDH1A1FYNADORA1FCGR3BFCGR1A
SCHEMBL6571015 0.85 ALDH1A1 (0.33) ALDH1A1TSHRTDP1MAPTMEN1
SCHEMBL6570636 0.82 TAAR1 (0.45) FYNADORA1MAPTCHRM3EGFR
SCHEMBL6570742 0.81 PTGDR2 (0.35) ALDH1A1FYNSTK4STK3PTGDR2
SCHEMBL6570922 0.81 PTGDR2 (0.44) ALDH1A1TDP1ADORA1PTGDR2MAP4K4
SCHEMBL6570749 0.80 PIK3CG (0.41) ALDH1A1TDP1ADORA1FCGR3BFCGR1A
Hydrochloric Acid SCHEMBL6573152 0.80 PTGDR2 (0.43) ALDH1A1TDP1ADORA1PTGDR2MAP4K4
SCHEMBL6573384 0.79 ADORA1 (0.51) ALDH1A1ADORA1STK4STK3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed