SCHEMBL6572723

SCHEMBL6572723

O=P(Cl)(CCl)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
CA5A P35218 1/20 0.44
ALDH1A1 P00352 4/20 0.43
GAA P10253 2/20 0.43
HTT P42858 2/20 0.43
MAPT P10636 2/20 0.43
ALPG P10696 1/20 0.43
ALOX12 P18054 1/20 0.43
NPY1R P25929 1/20 0.43
NPY2R P49146 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
USP2 O75604 1/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
RECQL P46063 1/20 0.39
LMNA P02545 1/20 0.39
ACHE P22303 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11418157 0.81 CFTR (0.46) CFTRCA2CA4CA5AALDH1A1
SCHEMBL7364597 0.78 ALDH1A1 (0.48) CFTRCA2CA4CA5AALDH1A1
SCHEMBL10876541 0.77 ALDH1A1 (0.56) CFTRCA2CA4CA5AALDH1A1
SCHEMBL11587700 0.77 CFTR (0.46) CFTRCA2CA4CA5AALDH1A1
Methylene Chloride SCHEMBL28537220 0.77 CFTR (0.46) CFTRCA2CA4CA5AALDH1A1
SCHEMBL28979738 0.74 ALDH1A1 (0.53) CFTRCA2CA4CA5AALDH1A1
SCHEMBL95882 0.73 CA2 (0.52) CFTRCA2CA4CA5AALDH1A1
SCHEMBL140712 0.73 CA2 (0.52) CFTRCA2CA4CA5AALDH1A1
SCHEMBL28809780 0.73 CA2 (0.52) CFTRCA2CA4CA5AALDH1A1
SCHEMBL7058667 0.72 AOX1 (0.53) CFTRCA2CA4CA5AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0642507-B1 TRANSITION STATE ANALOGUES OF COCAINE, THEIR USE FOR PRODUCING CATALYTIC ANTIBODIES AGAINST COCAINE AND USE OF THE SAME IN DIAGNOSIS AND THERAPY UNIV COLUMBIA (US) 2004-02-04 EP disclosed
US-6566084-B1 Detecting hydrolysis of cocaine compound; obtain cocaine mixture, incubate with antibody, monitor generation of benzoic zacid THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2003-05-20 US disclosed
US-6184013-B1 ANTIBODY FOR REDUCING CONCENTRATION OF DRUG IN PATIENT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2001-02-06 US disclosed
US-5990285-A ANTIBODY CAPABLE OF BINDING A TRANSITION STATE ANALOG FOR THE HYDROLYSIS OF COCAINE BENZOYL ESTER GROUP; TREATMENT OF DRUG ABUSE, DRUG DEPENDENCE, OVERDOSES THE TRUSTEES OF COLUMBIA UNIVERSITY (US) 1999-11-23 US disclosed
US-5977314-A ANTIBODY CAPABLE OF CATALYZING THE HYDROLYSIS OF COCAINE AT BENZOYL ESTER GROUP AND AGAINST SPECIFIC STRUCTURAL COMPOUNDS LISTED; FOR DECREASING CONCENTRATION OF COCAINE IN A SUBJECT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1999-11-02 US disclosed
EP-0642507-A4 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME. 1995-03-29 EP disclosed
EP-0642507-A1 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME The Trustees of Columbia University in the City of New York (US) 1995-03-15 EP disclosed
WO-1993020076-A1 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1993-10-14 WO disclosed
US-3943170-A Process for the preparation of halo-methylphosphinic acid halides HOECHST AKTIENGESELLSCHAFT (DT) 1976-03-09 US disclosed