SCHEMBL6572936

SCHEMBL6572936

BrCCCOc1cccc2oc3ccccc3c12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.47
KCNA3 P22001 4/20 0.43
MAOA P21397 2/20 0.43
BCL2 P10415 1/20 0.41
BCL2L1 Q07817 1/20 0.41
MCL1 Q07820 1/20 0.41
BAD Q92934 1/20 0.41
CYP2A6 P11509 1/20 0.40
HTR1B P28222 4/20 0.39
CDC25A P30304 1/20 0.38
CDC25B P30305 1/20 0.38
CDC25C P30307 1/20 0.38
SLC6A4 P31645 1/20 0.36
HRH1 P35367 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GLA P06280 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10431487 0.85 ADRB2 (0.48) ADRB2KCNA3MAOABCL2BCL2L1
SCHEMBL5747324 0.84 HTR1B (0.58) ADRB2KCNA3MAOABCL2BCL2L1
SCHEMBL12967977 0.84 CDC25A (0.52) ADRB2KCNA3MAOACYP2A6HTR1B
SCHEMBL15473271 0.82 CYP2A6 (0.59) ADRB2KCNA3MAOACYP2A6HTR1B
SCHEMBL5748254 0.81 XDH (0.57) ADRB2HTR1BALDH1A1
SCHEMBL5745193 0.80 HTR1B (0.61) ADRB2MAOAHTR1BHRH1
SCHEMBL5745016 0.80 SLC6A4 (0.61) ADRB2MAOAHTR1BSLC6A4HRH1
SCHEMBL9615135 0.79 LOXL2 (0.48) ADRB2KCNA3MAOABCL2BCL2L1
SCHEMBL5748059 0.79 POLB (0.53) ADRB2HTR1BKDM4EALDH1A1SMN1; SMN2
SCHEMBL12958219 0.78 ADRB2 (0.54) ADRB2KCNA3MAOABCL2BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392637-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2004-03-03 EP disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 WO disclosed