Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022754 | 0.77 | OPRM1 (0.82) | OPRM1OPRL1OPRD1OPRK1CCR3 | |
| SCHEMBL25340627 | 0.71 | OPRM1 (0.46) | OPRM1OPRL1OPRD1OPRK1SLC6A2 | |
| SCHEMBL15043692 | 0.68 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3CNR1ALDH1A1 | |
| SCHEMBL10726449 | 0.68 | SLC6A4 (0.48) | CCR3SLC6A2SLC6A4SLC6A3CNR1 | |
| SCHEMBL25341004 | 0.68 | DPP4 (0.53) | OPRM1OPRL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22815331 | 0.68 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3EPHX2 | |
| SCHEMBL25340130 | 0.68 | ALOX15 (0.45) | OPRM1OPRL1OPRD1OPRK1SLC6A2 | |
| SCHEMBL12981695 | 0.67 | OPRM1 (0.44) | OPRM1OPRL1OPRD1OPRK1SLC6A2 | |
| SCHEMBL367356 | 0.67 | DPP4 (0.57) | OPRM1OPRL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL435378 | 0.66 | ALDH1A1 (0.51) | SLC6A2SLC6A4SLC6A3CNR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406858-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANOLS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008370-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANOLS | Grünenthal GmbH (DE) | 2003-01-30 | — | — | WO | disclosed |