Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14926969 | 0.73 | PNMT (0.49) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL2462740 | 0.73 | DAO (0.70) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL2461710 | 0.73 | ALDH1A1 (0.70) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL29624790 | 0.71 | ALDH1A1 (0.68) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL29624775 | 0.71 | ALDH1A1 (0.68) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL3649120 | 0.71 | ALDH1A1 (0.68) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL765302 | 0.69 | PNMT (0.51) | PNMTALDH1A1HPGDTP53MAPK1 | |
| SCHEMBL31684434 | 0.69 | SIGMAR1 (0.44) | PNMTALDH1A1NOTUMDAOMEN1 | |
| SCHEMBL6421837 | 0.68 | PNMT (1.00) | PNMTALDH1A1NOTUMDAO | |
| SCHEMBL29676628 | 0.68 | PNMT (0.58) | PNMTALDH1A1HPGDTP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409476-A1 | PHARMACEUTICAL COMPOUNDS WITH SEROTONIN RECEPTOR ACTIVITY | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003006455-A1 | PHARMACEUTICAL COMPOUNDS WITH SEROTONIN RECEPTOR ACTIVITY | ELI LILLY AND COMPANY (US) | 2003-01-23 | — | — | WO | disclosed |