Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425058 | 0.89 | FFAR1 (0.47) | FFAR1LOXL2LMNANPY5RTDP1 | |
| SCHEMBL7178176 | 0.87 | IAPP (0.53) | FFAR1LOXL2LMNANPY5RTDP1 | |
| SCHEMBL6571641 | 0.86 | HRH1 (0.50) | FFAR1LOXL2LMNATDP1HDAC2 | |
| SCHEMBL27581983 | 0.86 | MMP12 (0.61) | FFAR1LMNANPY5RTDP1HDAC2 | |
| SCHEMBL333186 | 0.84 | FFAR1 (0.70) | FFAR1LMNANPY5RTDP1 | |
| SCHEMBL3937604 | 0.82 | FFAR1 (0.46) | FFAR1LOXL2LMNANPY5RTDP1 | |
| SCHEMBL1677975 | 0.82 | ALDH1A1 (0.63) | FFAR1LOXL2LMNANPY5RTDP1 | |
| SCHEMBL660683 | 0.82 | LOXL2 (0.52) | FFAR1LOXL2LMNANPY5RTDP1 | |
| SCHEMBL4662980 | 0.82 | FFAR1 (0.49) | FFAR1LOXL2LMNANPY5RTDP1 | |
| Hydrochloric Acid SCHEMBL8937697 | 0.82 | FFAR1 (0.68) | FFAR1LMNANPY5RTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316946-B | A kind of α of Ciprofloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-12-11 | — | — | CN | disclosed |
| CN-106316948-B | A kind of α of N- methyl Ciprofloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-12-11 | — | — | CN | disclosed |
| CN-106316945-B | A kind of α of pefloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-12-11 | — | — | CN | disclosed |
| CN-106316947-B | A kind of α of Norfloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-106317014-B | A kind of α of Lomefloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-106279019-B | A kind of α of Enrofloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-106316944-B | A kind of α of fleraxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-106317083-B | A kind of α of Rufloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | 河南大学 | 2018-08-31 | — | — | CN | disclosed |
| CN-106317074-B | A kind of α of Ofloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | HENAN UNIVERSITY (CN) | 2018-08-31 | — | — | CN | disclosed |
| CN-106317073-B | A kind of α of lavo-ofloxacin, alpha, beta-unsaturated ketone derivative and its preparation method and application | HENAN UNIVERSITY (CN) | 2018-08-31 | — | — | CN | disclosed |
| CN-102216299-A | 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer | MERCK PATENT GMBH | 2011-10-12 | — | — | CN | disclosed |
| CN-101765602-A | Derivatives of 6-cycloamino-3- (pyridin-4-yl) imidazo [1,2-b ] pyridazine, preparation thereof and therapeutic use thereof | SANOFI AVENTIS | 2010-06-30 | — | — | CN | disclosed |
| EP-1420009-A2 | Novel amino acid derivatives with improved multi-drug resistance activity | Vertex Pharmaceuticals Incorporated (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-0797567-B1 | NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY | VERTEX PHARMA (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6284778-B1 | NEUROTROPHIC AGENT | VERTEX PHARMACEUTICALS INCORPORATED | 2001-09-04 | — | — | US | disclosed |
| US-6172086-B1 | TREATING PARKINSON*S DISEASE, ALZHIEMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS AND OTHER NERVOUS SYSTEM DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED | 2001-01-09 | — | — | US | disclosed |
| US-5840736-A | PEPTIDES FOR NERVE GROWTH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0797567-A1 | NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY | Vertex Pharmaceuticals Incorporated (US) | 1997-10-01 | — | — | EP | disclosed |
| US-5543423-A | USED IN MULTI-DRUG RESISTANCE CANCER THERAPY | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-08-06 | — | — | US | disclosed |
| WO-1996015101-A1 | NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1996-05-23 | — | — | WO | disclosed |