SCHEMBL6574425

SCHEMBL6574425

Nc1cc(-c2ccc(Cl)cc2Cl)c(N)c(CCO)c1CCO

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.39
CYP3A4 P08684 1/20 0.39
DPP4 P27487 5/20 0.37
DPP8 Q6V1X1 3/20 0.36
HSP90AA1 P07900 2/20 0.36
HSP90AB1 P08238 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MGAM O43451 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
RAB9A P51151 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
TP53 P04637 1/20 0.35
AHR P35869 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SRD5A2 P31213 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574401 0.71 USP7 (0.42)
SCHEMBL23831996 0.71 CYP3A4 (0.37) TSHRCYP3A4KDM4EALDH1A1GAA
SCHEMBL6570707 0.71 HTR7 (0.36) TSHRCYP3A4DPP4ALDH1A1
SCHEMBL6573036 0.70 MAPT (0.31) KDM4EALDH1A1RAB9ASMN1; SMN2CYP1A2
SCHEMBL6572300 0.69
SCHEMBL7460452 0.69 PLA2G10 (0.33)
SCHEMBL7686229 0.69 SLC6A2 (0.30)
SCHEMBL4053905 0.68 ALDH1A1 (0.38) TSHRCYP3A4ALDH1A1GAATP53
SCHEMBL11214035 0.68 TSHR (0.58) TSHRCYP3A4DPP4HSP90AA1HSP90AB1
SCHEMBL464507 0.67 AHR (0.64) TSHRCYP3A4HSP90AA1HSP90AB1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed