SCHEMBL6574556

SCHEMBL6574556

COCCc1c(N)cc(-c2ccccc2OC)c(N)c1CCOC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 9/20 0.41
ALDH1A1 P00352 5/20 0.40
ADRA2B P18089 1/20 0.40
PTGS1 P23219 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
HTR1A P08908 3/20 0.39
HTR1D P28221 3/20 0.39
HTR1B P28222 3/20 0.39
HTR2A P28223 3/20 0.39
HTR1E P28566 3/20 0.39
HTR2B P41595 3/20 0.39
HTR5A P47898 3/20 0.39
HTR6 P50406 3/20 0.39
HSD17B10 Q99714 2/20 0.38
HTR2C P28335 1/20 0.38
LMNA P02545 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
HSP90AA1 P07900 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574519 0.83 PLA2G7 (0.39) HTR7ALDH1A1TDP1HTR1AHTR1D
SCHEMBL6571021 0.74 BACE1 (0.34) ALDH1A1HSD17B10LMNACYP3A4KDM4E
SCHEMBL8098435 0.73 MCL1 (0.31) ALDH1A1TDP1LMNA
SCHEMBL6575169 0.73
SCHEMBL6571990 0.72 PRKCZ (0.33) ALDH1A1CYP1A2CYP2C19KDM4ERAB9A
SCHEMBL6571862 0.69 GAA (0.42) ALDH1A1TDP1HSD17B10LMNAKDM4E
SCHEMBL395260 0.69 ALDH1A1 (0.67) HTR7ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL12005742 0.68 ALDH1A1 (0.34) ALDH1A1ADRA2BPTGS1TDP1HSD17B10
SCHEMBL1922106 0.68 ALDH1A1 (0.59) HTR7ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL301996 0.68 CA1 (0.71) HTR7ALDH1A1ADRA2BPTGS1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed