Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26841188 | 0.84 | SLC6A2 (0.52) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL13416766 | 0.84 | SLC6A2 (0.52) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL13417340 | 0.84 | SLC6A2 (0.52) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL1389408 | 0.79 | SLC6A2 (0.50) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL6575401 | 0.78 | AOC3 (0.54) | SLC6A2SLC6A4SLC6A3ADRA2CADRA2A | |
| SCHEMBL20008956 | 0.76 | TRPA1 (0.57) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL105769 | 0.76 | TRPA1 (0.57) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL597722 | 0.74 | SLC6A2 (0.48) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B | |
| SCHEMBL6575399 | 0.73 | SLC6A2 (0.57) | TRPA1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL13417391 | 0.73 | SLC6A2 (0.48) | TRPA1SLC6A2SLC6A4SLC6A3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236118-A1 | Pyrrolidine derivatives and method of synthesizing these | EIZAI CO., LTD (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1413574-A1 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | Eizai Co., Ltd. (JP) | 2004-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236118-A1 | Pyrrolidine derivatives and method of synthesizing these | ADH1C, ADH5, ADH1A | TRPA1 4750/4885SLC6A2 3620/4885SLC6A4 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.