Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580121 | 0.88 | MTNR1A (0.51) | GFERHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6575496 | 0.85 | HTR6 (0.56) | GFERMAPTTP53LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL6575484 | 0.84 | HTR6 (0.54) | GFERMAPTTP53LMNAMEN1 | |
| SCHEMBL6575604 | 0.81 | MTNR1A (0.47) | GFERHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3565055 | 0.77 | HTR6 (0.45) | SLC6A2HTR2AMEN1KMT2ASFRP1 | |
| SCHEMBL6575539 | 0.77 | MTNR1A (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6575580 | 0.76 | HTR6 (0.57) | GFERMAPTTP53LMNAMEN1 | |
| SCHEMBL2077801 | 0.75 | CHRNB2 (0.67) | GFERMAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6580144 | 0.75 | HTR6 (0.56) | GFERMAPTTP53LMNAMEN1 | |
| SCHEMBL6579555 | 0.75 | HTR6 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6565829-B2 | Psychological disorders; central nervous system disorders | PHARMACIA & UPJOHN COMPANY | 2003-05-20 | — | — | US | claimed |
| US-20030060498-A1 | 5-arylsulfonyl indoles useful for treating disease | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | claimed |
| EP-1411925-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6565829-B2 | Psychological disorders; central nervous system disorders | PHARMACIA & UPJOHN COMPANY | 2003-05-20 | — | — | US | disclosed |
| US-20030060498-A1 | 5-arylsulfonyl indoles useful for treating disease | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | disclosed |
| WO-2003011284-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060498-A1 | 5-arylsulfonyl indoles useful for treating disease | IDO1, HTR5A, IDO2 | GFER 2455/4885HDAC3 178/4885HDAC4 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.