Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12559590 | 0.79 | L3MBTL1 (0.54) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL5215688 | 0.78 | HPGD (0.53) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL5817493 | 0.78 | MGLL (0.43) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8613287 | 0.76 | MAPT (0.39) | KMT2AALDH1A1LMNAF2ELANE | |
| SCHEMBL11692973 | 0.75 | KMT2A (0.56) | KMT2AESR1GAAMEN1SMN1; SMN2 | |
| SCHEMBL1949985 | 0.75 | LMNA (0.64) | KMT2AALDH1A1LMNAF2ELANE | |
| SCHEMBL29846831 | 0.74 | PBRM1 (0.46) | ESR1ESR2PBRM1 | |
| SCHEMBL6073803 | 0.74 | PBRM1 (0.46) | ESR1ESR2PBRM1 | |
| SCHEMBL3431666 | 0.74 | DRD2 (0.44) | KMT2ANPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL5218324 | 0.73 | SLC6A2 (0.50) | KMT2AALDH1A1LMNAF2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |