Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613287 | 0.75 | MAPT (0.39) | KMT2AGAAMAPTALDH1A1LMNA | |
| SCHEMBL6576642 | 0.72 | POLB (0.41) | ARSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL17657221 | 0.71 | DRD2 (0.36) | KDM4EALDH1A1DRD2HTR1DDRD3 | |
| SCHEMBL8771675 | 0.71 | DRD2 (0.39) | KDM4EALDH1A1DRD2HTR1DDRD3 | |
| SCHEMBL8616526 | 0.69 | RARB (0.42) | ARMAPTLMNATSHR | |
| SCHEMBL1091438 | 0.69 | PGR (0.45) | SMN1; SMN2KDM4EALDH1A1LMNADRD2 | |
| SCHEMBL15280722 | 0.69 | HTR1D (0.36) | MAPTDRD2HTR1DDRD3HSD11B1 | |
| SCHEMBL2750188 | 0.68 | CA2 (0.57) | SMN1; SMN2GAALMNATSHRDRD2 | |
| Hydrogen Sulfide SCHEMBL6248782 | 0.66 | CA2 (0.55) | SMN1; SMN2GAALMNATSHRDRD2 | |
| SCHEMBL17657225 | 0.66 | DRD2 (0.33) | SMN1; SMN2ALDH1A1DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5739338-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS, VISION DEFECTS, VIRICIDES, IMMUNOSUPPRESSANTS | ALLERGAN (US) | 1998-04-14 | — | — | US | disclosed |