Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1091438 | 0.89 | PGR (0.45) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL17393794 | 0.80 | HSD11B1 (0.41) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL6086547 | 0.77 | KDM4E (0.59) | ALDH1A1KDM4EKLK7 | |
| SCHEMBL1140782 | 0.77 | CHRM1 (0.41) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL8597253 | 0.77 | PDE3B (0.47) | PGRCA1CA2ALDH1A1KDM4E | |
| SCHEMBL17020540 | 0.77 | HSD11B1 (0.37) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL1807301 | 0.76 | DRD2 (0.39) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL727285 | 0.75 | KDM4E (0.40) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL2455365 | 0.74 | HTR1D (0.39) | DRD2DRD3CHRM1DRD4HSD11B1 | |
| SCHEMBL17016644 | 0.74 | KDM4E (0.36) | DRD2DRD3CHRM1DRD4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |