Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 1.00 |
| ▸ | CASP1 | P29466 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CASP7 | P55210 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | ANPEP | P15144 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468786 | 0.88 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4781427 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8995319 | 0.84 | CASP1 (0.86) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9566650 | 0.83 | CASP1 (0.83) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10691705 | 0.82 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11866904 | 0.81 | MEN1 (1.00) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9566662 | 0.80 | CASP1 (0.73) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9468849 | 0.80 | NPC1 (0.67) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9566664 | 0.78 | NPC1 (0.65) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6581700 | 0.77 | TSHR (0.64) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192131-B1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER LAMBERT CO (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-1192131-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076969-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |