SCHEMBL6579334

SCHEMBL6579334

Clc1ccc(C(CCOC2CCCCO2)Cn2ccnc2)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP8B1 Q9UNU6 1/20 0.43
CYP19A1 P11511 1/20 0.39
IDO1 P14902 1/20 0.38
KDM4C Q9H3R0 1/20 0.37
SLC6A3 Q01959 4/20 0.36
TACR2 P21452 2/20 0.35
FNTA P49354 2/20 0.35
FNTB P49356 2/20 0.35
PGGT1B P53609 2/20 0.35
TBXAS1 P24557 1/20 0.35
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
OGG1 O15527 1/20 0.35
EPHA2 P29317 1/20 0.34
KCNA5 P22460 1/20 0.34
SCN5A Q14524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6579345 0.80 SLC6A3 (0.45) KDM4CSLC6A3L3MBTL1KCNA5SCN5A
SCHEMBL5858706 0.80 SLC6A3 (0.42) KDM4CSLC6A3L3MBTL1KCNA5SCN5A
SCHEMBL8782641 0.78 SLC6A3 (0.46) KDM4CSLC6A3L3MBTL1EPHA2KCNA5
Hydrochloric Acid SCHEMBL8369516 0.77 SLC6A3 (0.45) KDM4CSLC6A3L3MBTL1EPHA2
SCHEMBL8971968 0.76 SLC6A3 (0.42) KDM4CSLC6A3L3MBTL1KCNA5SCN5A
SCHEMBL6581692 0.75 CYP8B1 (0.47) CYP8B1CYP19A1IDO1TACR2
SCHEMBL9053699 0.75 SLC6A3 (0.44) KDM4CSLC6A3L3MBTL1EPHA2KCNA5
SCHEMBL8592474 0.75 SLC6A3 (0.44) KDM4CSLC6A3EPHA2
SCHEMBL6579809 0.75 KDM4C (0.36) KDM4CSLC6A3TACR2
SCHEMBL6577520 0.74 SLC6A3 (0.44) KDM4CSLC6A3L3MBTL1KCNA5SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994876-B1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LTD (GB) 2004-09-08 EP disclosed
US-6380396-B1 CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS PFIZER INC. 2002-04-30 US disclosed
US-6207678-B1 USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS PFIZER INC 2001-03-27 US disclosed