Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 5/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579428 | 0.84 | SLC6A3 (0.37) | KDM4CSLC6A3MCHR1TACR2 | |
| SCHEMBL6579271 | 0.84 | MCHR1 (0.37) | KDM4CSLC6A3MEN1KMT2AMCHR1 | |
| SCHEMBL6579334 | 0.75 | CYP8B1 (0.43) | KDM4CSLC6A3TACR2 | |
| SCHEMBL8479637 | 0.74 | TACR2 (0.43) | SLC6A3MEN1KMT2ATACR2 | |
| SCHEMBL6947372 | 0.74 | KDM4C (0.39) | KDM4CSLC6A3MEN1KMT2AMCHR1 | |
| SCHEMBL6579345 | 0.74 | SLC6A3 (0.45) | KDM4CSLC6A3MEN1KMT2A | |
| SCHEMBL5866431 | 0.74 | MCHR1 (0.44) | SLC6A3MEN1KMT2AMCHR1TACR2 | |
| SCHEMBL6422995 | 0.72 | TACR2 (0.58) | TACR2 | |
| SCHEMBL8706751 | 0.72 | SLC6A3 (0.48) | KDM4CSLC6A3MEN1KMT2A | |
| SCHEMBL5858706 | 0.72 | SLC6A3 (0.42) | KDM4CSLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994876-B1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2004-09-08 | — | — | EP | disclosed |
| US-6380396-B1 | CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| US-6207678-B1 | USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS | PFIZER INC | 2001-03-27 | — | — | US | disclosed |
| EP-0994876-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057972-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1998-12-23 | — | — | WO | disclosed |