Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.57 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28478190 | 0.87 | ALDH1A1 (0.74) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL9107325 | 0.87 | MAPK1 (0.61) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL7951628 | 0.85 | L3MBTL1 (0.60) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL28410934 | 0.85 | CFTR (0.61) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL29847379 | 0.83 | CASP1 (0.57) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL6581741 | 0.83 | CASP1 (0.57) | CFTRMAPK1CASP1CASP7CYP2C19 | |
| SCHEMBL5717623 | 0.82 | ALDH1A1 (0.67) | MAPK1CASP1CASP7CYP2C19ALDH1A1 | |
| SCHEMBL9103612 | 0.81 | MAPK1 (0.62) | MAPK1CASP1CASP7CYP2C19ALDH1A1 | |
| SCHEMBL8861179 | 0.81 | ALDH1A1 (0.70) | MAPK1CASP1CASP7CYP2C19ALDH1A1 | |
| SCHEMBL7829144 | 0.81 | CASP1 (0.55) | CFTRMAPK1CASP1CASP7CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048655-B1 | 1,2-DIHYDRO-2-OXOQUINOLINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-6380384-B1 | ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2002-04-30 | — | — | US | disclosed |
| US-20020049323-A1 | 1,2-Dihydro-2-oxoquinoline derivatives | NAKAZATO ATSURO (JP) | 2002-04-25 | — | — | US | disclosed |
| US-6329389-B1 | HETEROCYCLIC AMINES AND DERIVATIVES, SOMATOSTATIN AND ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-12-11 | — | — | US | disclosed |
| US-6329525-B1 | 1,2-Dihydro-2-oxoquinoline derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070054-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-1048655-A1 | 1,2-DIHYDRO-2-OXOQUINOLINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999052875-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049323-A1 | 1,2-Dihydro-2-oxoquinoline derivatives | NR5A1, SRD5A1, SRD5A2 | CFTR 1188/4885MAPK1 511/4885CASP1 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.