Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | SI | P14410 | 4/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659012 | 0.88 | GLA (0.41) | PDPK1GLAMGAMGAASI | |
| SCHEMBL658185 | 0.85 | L3MBTL1 (0.39) | PDPK1L3MBTL1CYP2C9KMT2A | |
| SCHEMBL657804 | 0.82 | SRD5A2 (0.38) | L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL656363 | 0.81 | ALDH1A1 (0.45) | GLAMGAMGAASIMGAM2 | |
| SCHEMBL658601 | 0.80 | PDPK1 (0.41) | PDPK1L3MBTL1HPGDCYP2C9KMT2A | |
| SCHEMBL657352 | 0.78 | PDPK1 (0.47) | PDPK1SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL657975 | 0.77 | PDPK1 (0.69) | PDPK1GLAMGAMGAASI | |
| SCHEMBL656175 | 0.76 | KMT2A (0.47) | PDPK1L3MBTL1HPGDCYP2C9HSD17B10 | |
| SCHEMBL10252971 | 0.75 | PDPK1 (0.52) | PDPK1GLAMGAMGAASI | |
| SCHEMBL657877 | 0.75 | CYP2C9 (0.50) | PDPK1GAAL3MBTL1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | PDPK1 109/4885GLA 2734/4885MGAM 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.