SCHEMBL6579969

SCHEMBL6579969

O=C(CO)c1cccc(NC(=O)c2ccc(Cc3ccc(Cl)cc3)cc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.58
NPC1 O15118 5/20 0.58
RAB9A P51151 5/20 0.58
MEN1 O00255 5/20 0.58
POLB P06746 2/20 0.58
SENP8 Q96LD8 1/20 0.58
SENP7 Q9BQF6 1/20 0.58
SENP6 Q9GZR1 1/20 0.58
KCNK3 O14649 3/20 0.55
KCNK9 Q9NPC2 2/20 0.50
MET P08581 1/20 0.49
PTGS2 P35354 1/20 0.49
KDM4E B2RXH2 1/20 0.49
GAA P10253 1/20 0.49
ALDH1A1 P00352 2/20 0.49
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HPGD P15428 1/20 0.49
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6580464 0.87 NR1H4 (0.58) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6577542 0.86 KMT2A (0.80) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6582800 0.84 KCNK9 (0.64) KMT2ANPC1RAB9AMEN1KCNK3
SCHEMBL6580260 0.83 TRPV1 (0.56) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6346822 0.82 KCNK3 (0.71) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6577323 0.82 NLRP3 (0.67) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6580248 0.80 NR1H4 (0.57) KMT2ANPC1RAB9AMEN1POLB
SCHEMBL6577998 0.80 NR1H4 (0.65) KMT2ARAB9AMEN1POLBKCNK3
SCHEMBL6577802 0.80 NR1H4 (0.62) KMT2ARAB9AMEN1POLBKCNK3
SCHEMBL6579939 0.79 TRPV1 (0.67) KMT2ANPC1RAB9AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0716088-B1 PROCESS FOR PRODUCING 2-(TETRAZOL-5-YL)-4-OXO-4H-BENZOPYRANS SUMITOMO CHEMICAL CO (JP) 2004-02-18 EP disclosed
US-5597929-A Production process of 2-(tetrazol-5-yl)-4-oxo-4H-benzopyran SUMITOMO CHEMICAL CO., LTD. (JP) 1997-01-28 US disclosed
EP-0716088-A1 PROCESS FOR PRODUCING 2-(TETRAZOL-5-YL)-4-OXO-4H-BENZOPYRANS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-12 EP disclosed