Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 7/20 | 0.59 |
| ▸ | HTR1A | P08908 | 12/20 | 0.57 |
| ▸ | HTR3A | P46098 | 12/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233944 | 0.87 | HTR3A (0.61) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL12176443 | 0.83 | HTR1A (0.49) | HTR1AHTR3A | |
| SCHEMBL4328782 | 0.81 | ADRB1 (0.63) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL255418 | 0.81 | HTR1A (0.62) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL29805912 | 0.81 | HTR1A (0.62) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL16727175 | 0.81 | ALDH1A1 (0.50) | HTR1A | |
| SCHEMBL30511075 | 0.81 | ADRB1 (0.63) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL13419460 | 0.81 | HTR3A (0.56) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL15597488 | 0.80 | MAPT (0.53) | HTR1AHTR3ADRD2DRD3ADRB2 | |
| Hydrochloric Acid SCHEMBL2959720 | 0.80 | HTR1A (0.65) | ADRB1HTR1AHTR3ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |
| EP-1200406-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005765-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-01-25 | — | — | WO | disclosed |