Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 7/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.44 |
| ▸ | HTR3B | O95264 | 3/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24522235 | 0.83 | ALDH1A1 (0.52) | ADRB1HTR1AADRA1BTP53THRB | |
| SCHEMBL4328782 | 0.81 | ADRB1 (0.63) | ADRB1DRD2DRD3HTR3AHTR1A | |
| SCHEMBL30511075 | 0.81 | ADRB1 (0.63) | ADRB1DRD2DRD3HTR3AHTR1A | |
| Hydrochloric Acid SCHEMBL3649806 | 0.80 | ADRB1 (0.61) | ADRB1DRD2DRD3HTR3AHTR1A | |
| Hydrochloric Acid SCHEMBL6965349 | 0.80 | ADRB1 (0.61) | ADRB1DRD2DRD3HTR3AHTR1A | |
| Hydrochloric Acid SCHEMBL29832037 | 0.80 | ADRB1 (0.61) | ADRB1DRD2DRD3HTR3AHTR1A | |
| SCHEMBL6195922 | 0.79 | ADRB1 (0.59) | ADRB1DRD2DRD3HTR3AHTR1A | |
| SCHEMBL6580002 | 0.79 | ADRB1 (0.59) | ADRB1DRD2DRD3HTR3AHTR1A | |
| SCHEMBL23339696 | 0.79 | ALDH1A1 (0.45) | ADRB1DRD2DRD3HTR3AHTR1A | |
| SCHEMBL7537170 | 0.79 | ADRB1 (0.58) | ADRB1HTR3AHTR1AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |
| EP-1200406-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005765-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-01-25 | — | — | WO | disclosed |