Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | UBE2M | P61081 | 2/20 | 0.50 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589154 | 0.90 | HIF1A (0.59) | HIF1AEPAS1CHRM2CHRM5CHRM1 | |
| SCHEMBL2586188 | 0.85 | HDAC3 (0.54) | CHRM4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17675459 | 0.83 | SIGMAR1 (0.63) | UBE2MDCUN1D1SIGMAR1DRD2DRD4 | |
| SCHEMBL7806887 | 0.81 | NAMPT (0.56) | NR3C1 | |
| SCHEMBL7086952 | 0.76 | PLG (0.53) | — | |
| SCHEMBL7079790 | 0.76 | S1PR1 (0.51) | HIF1AEPAS1 | |
| SCHEMBL7086631 | 0.76 | NPC1 (0.54) | — | |
| SCHEMBL5153696 | 0.76 | APOB (0.52) | — | |
| SCHEMBL2588205 | 0.75 | HIF1A (0.64) | HIF1AEPAS1CHRM2FAAH | |
| SCHEMBL7137493 | 0.75 | CYP19A1 (0.49) | HIF1AEPAS1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379515-A1 | LIPID LOWERING BIPHENYLCARBOXAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002081460-A1 | LIPID LOWERING BIPHENYLCARBOXAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-17 | — | — | WO | disclosed |