SCHEMBL6580879

SCHEMBL6580879

CC1(C)CN(Cc2ccccc2)CCC1=O.CC1(C)CNCCC1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.47
TSHR P16473 2/20 0.47
CYP3A4 P08684 1/20 0.47
GAA P10253 1/20 0.46
SIGMAR1 Q99720 2/20 0.43
NR3C1 P04150 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
SLC6A5 Q9Y345 1/20 0.41
CLPP Q16740 2/20 0.39
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39
ACHE P22303 3/20 0.39
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
HTR2C P28335 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL653269 0.88 GAA (0.57) CYP2D6TSHRGAASIGMAR1NR3C1
SCHEMBL16903456 0.80 GAA (0.54) CYP2D6TSHRCYP3A4GAASIGMAR1
SCHEMBL6589016 0.80 CXCR3 (0.41) CYP2D6TSHRCYP3A4GAASIGMAR1
SCHEMBL3140906 0.76 KDM4E (0.46) GAASIGMAR1ALDH1A1CLPP
SCHEMBL4364213 0.73 GAA (0.53) CYP2D6TSHRGAASIGMAR1NR3C1
SCHEMBL6581527 0.72 GAA (0.51) CYP2D6TSHRCYP3A4GAASIGMAR1
SCHEMBL28040054 0.72 ALDH1A1 (0.35) ALDH1A1DDB1CRBNHTR2C
SCHEMBL4369263 0.72 GAA (0.50) CYP2D6TSHRGAASIGMAR1NR3C1
SCHEMBL3315042 0.71 NR3C1 (0.49) CYP2D6CYP3A4GAASIGMAR1NR3C1
SCHEMBL13090069 0.71 NR3C1 (0.52) CYP2D6TSHRCYP3A4GAASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1453824-A1 NEW GENERATION TRIPLE-TARGETING, CHIRAL, BROAD-SPECTRUM ANTIMICROBIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION, COMPOSITIONS AND USE AS MEDICAMENTS Wockhardt Limited (IN) 2004-09-08 EP disclosed
EP-1392677-A2 CHIRAL BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS Wockhardt Limited (IN) 2004-03-03 EP disclosed
WO-2003050107-A1 NEW GENERATION TRIPLE-TARGETING, CHIRAL, BROAD-SPECTRUM ANTIMICROBIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION, COMPOSITIONS AND USE AS MEDICAMENTS WOCKHARDT LIMITED (IN) 2003-06-19 WO disclosed
WO-2002085886-A2 CHIRAL, BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS WOCKHARDT LIMITED (IN) 2002-10-31 WO disclosed